The chiral edge modes of a topological superconductor can transport fermionic quasiparticles with Abelian exchange statistics, but they can also transport non-Abelian anyons: edge vortices bound to a π-phase domain wall that propagates along the boundary. A pair of such edge vortices is injected by the application of an h/2e flux bias over a Josephson junction. Existing descriptions of the injection process rely on the instantaneous scattering approximation of the adiabatic regime [Beenakker et al., Phys. Rev. Lett. 122, 146803 (2019)], where the internal dynamics of the Josephson junction is ignored. Here, we go beyond that approximation in a time-dependent many-body simulation of the injection process, followed by a braiding of mobile edge vortices with a pair of immobile Abrikosov vortices in the bulk of the superconductor. Our simulation sheds light on the properties of the Josephson junction needed for a successful implementation of a flying topological qubit.
View lessWe investigate magnetotransport across an interface between two Weyl semimetals whose Weyl nodes project onto different interface momenta. Such an interface generically hosts Fermi arcs that connect Weyl nodes of identical chirality in different Weyl semimetals (homochiral connectivity)—in contrast to surface Fermi arcs that connect opposite-chirality Weyl nodes within the same Weyl semimetal (heterochiral connectivity). We show that electron transport along homochiral-connectivity Fermi arcs, in the presence of a longitudinal magnetic field, results in a universal longitudinal magnetoconductance of e2/h per magnetic flux quantum. Furthermore, a weak tunnel coupling can result in a close encounter of two homochiral-connectivity Fermi arcs, enabling magnetic breakdown. Above the breakdown field the interface Fermi arc connectivity is effectively heterochiral, leading to a saturation of the conductance.
View lessIntroduction: Bloodwork is a widely used diagnostic tool in veterinary medicine, as diagnosis and therapeutic interventions often rely on blood biomarkers. However, biomarkers available in veterinary medicine often lack sensitivity or specificity. Mass spectrometry-based proteomics technology has been extensively used in the analysis of biological fluids. It offers excellent potential for a more comprehensive characterization of the plasma proteome in veterinary medicine.
Methods: In this study, we aimed to identify and quantify plasma proteins in a cohort of healthy dogs and compare two techniques for depleting high-abundance plasma proteins to enable the detection of lower-abundance proteins via label-free quantification liquid chromatography-mass spectrometry. We utilized surplus lithium-heparin plasma from 30 healthy dogs, subdivided into five groups of pooled plasma from 6 randomly selected individuals each. Firstly, we used a commercial kit to deplete high-abundance plasma proteins. Secondly, we employed an in-house method to remove albumin using Blue-Sepharose.
Results and discussion: Among all the samples, some of the most abundant proteins identified were apolipoprotein A and B, albumin, alpha-2-macroglobulin, fibrinogen beta chain, fibronectin, complement C3, serotransferrin, and coagulation factor V. However, neither of the depletion techniques achieved significant depletion of highly abundant proteins. Despite this limitation, we could detect and quantify many clinically relevant proteins. Determining the healthy canine proteome is a crucial first step in establishing a reference proteome for canine plasma. After enrichment, this reference proteome can later be utilized to identify protein markers associated with different diseases, thereby contributing to the diagnosis and prognosis of various pathologies.
View lessThree-dimensional higher-order topological insulators can have topologically protected chiral modes propagating on their hinges. Hinges with two copropagating chiral modes can serve as a “beam splitter” between hinges with only a single chiral mode. Here we show how such a crystal, with Ohmic contacts attached to its hinges, can be used to realize a Mach-Zehnder interferometer. We present concrete calculations for a lattice model of a first-order topological insulator in a magnetic field, which, for a suitable choice of parameters, is an extrinsic second-order topological insulator with the required configuration of chiral hinge modes.
View lessAims: Heart failure (HF) does not only reduce the life expectancy in patients, but their life is also often limited by HF symptoms leading to a reduced quality of life (QoL) and a diminished exercise capacity. Novel parameters in cardiac imaging, including both global and regional myocardial strain imaging, promise to contribute to better patient characterization and ultimately to better patient management. However, many of these methods are not part of clinical routine yet, their associations with clinical parameters have been poorly studied. An imaging parameters that also indicate the clinical symptom burden of HF patients would make cardiac imaging more robust toward incomplete clinical information and support the clinical decision process.
Methods and results: This prospective study conducted at two centers in Germany between 2017 and 2018 enrolled stable outpatient subjects with HF [n = 56, including HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF)] and a control cohort (n = 19). Parameters assessed included measures for external myocardial function, for example, cardiac index and myocardial deformation measurements by cardiovascular magnetic resonance imaging, left ventricular global longitudinal strain (GLS), the global circumferential strain (GCS), and the regional distribution of segment deformation within the LV myocardium, as well as basic phenotypical characteristics including the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the 6-minute walk test (6MWT). If less than 80% of the LV segments are preserved in their deformation capacity the functional capacity by 6MWT (6 minutes walking distance: MyoHealth >= 80%: 579.8 +/- 177.6 m; MyoHealth 60-<80%: 401.3 +/- 121.7 m; MyoHealth 40-<60%: 456.4 +/- 68.9 m; MyoHealth < 40%: 397.6 +/- 125.9 m, overall p-value: 0.03) as well as the symptom burden are significantly impaired (NYHA class: MyoHealth >= 80%: 0.6 +/- 1.1 m; MyoHealth 60-p-value < 0.01). Differences were also observed in the perceived exertion assessed by on the Borg scale (MyoHealth >= 80%: 8.2 +/- 2.3 m; MyoHealth 60-p-value: 0.20) as well as quality of life measures (MLHFQ; MyoHealth >= 80%: 7.5 +/- 12.4 m; MyoHealth 60-p-value: 0.15)-while these differences were not significant.
Conclusion: The share of LV segments with preserved myocardial contraction promises to discriminate between symptomatic and asymptomatic subjects based on the imaging findings, even when the LV ejection fraction is preserved. This finding is promising to make imaging studies more robust toward incomplete clinical information.
View lessPressure overload hypertrophy of the left ventricle is a common result of many cardiovascular diseases. Androgens show anabolic effects in skeletal muscles, but also in myocardial hypertrophy. We carefully reviewed literature regarding possible effects of androgens on specific left ventricular hypertrophy in pressure overload conditions excluding volume overload conditions or generel sex differences.
This article interrogates the widely held, but rarely defended, view that states wield legitimate power over potential immigrants when and because they refrain from violating their human rights. I reconstruct a strong argument for this view, which turns on a claim about the limited power states claim over migrants. Drawing on recent empirical work, I show how this argument is inapplicable to the border regimes of a set of wealthy democracies. These regimes are characterized by a practice that is coordinated and extraterritorial in a way that undercuts the case for holding them to a minimal legitimacy standard. By participating in this practice, these states wield significant power over potential immigrants. I argue that this power exposes potential immigrants to novel risk, which in turn triggers a demand for the satisfaction of a higher standard of legitimation.
View lessBackground
Early negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence.
Methods
We acquired structural MRI from 321 participants at two sites across four time points from ages 14 to 22. We measured NLE with the Life Events Questionnaire at the first time point and depressive symptoms with the Center for Epidemiologic Studies Depression Scale at the fourth time point. Modeling latent growth curves, we tested whether OFC thinning mediates the effect of NLE on depressive symptoms.
Results
A higher burden of NLE, a thicker OFC at the age of 14, and an accelerated OFC thinning across adolescence predicted young adults' depressive symptoms. We did not identify an effect of NLE on OFC thickness nor OFC thickness mediating effects of NLE on depressive symptoms.
Conclusions
Using a complete longitudinal design with four waves, we show that NLE in childhood and early adolescence predict depressive symptoms in the long term. Results indicate that an accelerated OFC thinning may precede depressive symptoms. Assessment of early additionally to acute NLEs and neurodevelopment may be warranted in clinical settings to identify risk factors for depression.
View less[Fe]-hydrogenase harbors the iron-guanylylpyridinol (FeGP) cofactor, in which the Fe(II) complex contains acyl-carbon, pyridinol-nitrogen, cysteine-thiolate and two CO as ligands. Irradiation with UV-A/blue light decomposes the FeGP cofactor to a 6-carboxymethyl-4-guanylyl-2-pyridone (GP) and other components. Previous in vitro biosynthesis experiments indicated that the acyl- and CO-ligands in the FeGP cofactor can scramble, but whether scrambling occurred during biosynthesis or photolysis was unclear. Here, we demonstrate that the [18O1-carboxy]-group of GP is incorporated into the FeGP cofactor by in vitro biosynthesis. MS/MS analysis of the 18O-labeled FeGP cofactor revealed that the produced [18O1]-acyl group is not exchanged with a CO ligand of the cofactor, indicating that the acyl and CO ligands are scrambled during photolysis rather than biosynthesis, which ruled out any biosynthesis mechanisms allowing acyl/CO ligands scrambling. Time-resolved infrared spectroscopy indicated that an acyl-Fe(CO)3 intermediate is formed during photolysis, in which scrambling of the CO and acyl ligands can occur. This finding also suggests that the light-excited FeGP cofactor has a higher affinity for external CO. These results contribute to our understanding of the biosynthesis and photosensitive properties of this unique H2-activating natural complex.
View lessFamilial cancer burden and genetics play an increasingly important role in the early detection and prevention of gynecological cancers. However, people with hereditary cancer risks are often identified late when they already have cancer. We aimed at developing and evaluating a training concept for primary care gynecologists—iKNOWgynetics—to improve their knowledge and awareness of genetic cancer syndromes and their ability to identify patients with increased familial cancer risks based on up-to-date evidence and current guidelines (in Germany, primary care includes all doctors treating patients on an outpatient basis without a clear separation of the expertise of the doctor or of their specialty). Starting off with a needs assessment among primary care gynecologists, we developed and evaluated an online training concept—using a web-based learning platform in combination with a live virtual seminar—to convey practice-relevant knowledge about familial cancer. After registration, participants get access to the web-based learning platform (www.iknowgynetics.de) to prepare for the virtual seminars and to use it as online reference to re-access the contents after the training. Evaluation included multiple-choice (MC) questions on knowledge and participants' self-efficacy to implement the acquired knowledge, which were administered in a pre-post design. Of 109 participants, 103 (94.5%) filled out pre- and post-questionnaires. Eighty-five participants were gynecologists in primary care from Berlin (81.2%) and Brandenburg (18.8%) and had an average of 24.1 years (SD = 8.5 years) of professional experience. After the training, participants answered significantly more knowledge questions correctly (M = 15.2 of 17, SD = 1.3) than before (M = 13.8 of 17, SD = 1.7) (p < 0.01) and felt more confident to be able to apply referral criteria for specialized counseling in practice (p < 0.001). The online-based training iKNOWgynetics considers the busy schedule of primary care gynecologists and supports them in acquiring practice-relevant information on familial cancer risks and on how to identify healthy persons at risk, which may ultimately help to improve the prevention of gynecological cancers. In future studies, the reported concept could be transferred to other entities.
View lessThe growth, morphology, and structure of MnxAu1-x films on Cu(001) and Ag(001) are studied by means of low-energy electron diffraction (LEED), medium-energy electron diffraction, Auger electron spectroscopy, and scanning tunnelling microscopy. Different concentrations x from about 0.5 to 1 and thicknesses from0.2 to 12.9 ML of MnxAu1-x are examined. For several values of x, MnxAu1-x exhibits a c(2 x 2) superstructure pattern on Cu(001) when the total thickness is around or above 0.5 ML. Above 1 ML, LEED patterns of MnxAu1-x can be only observed on Ag(001), but not on Cu(001). LEED-I(V) is employed to deduce the vertical interlayer distance for as-grown and post-annealed films on Ag(001). Above 500 K, Ag from the substrate segregates into thefilms.
View lessLunar impact basins are critical markers to understand the early bombardment history. This study focuses on isostatic compensation processes at 16 lunar farside basins, exploring how long-term alteration processes affect estimates of impactor sizes and timing. Using a lithospheric flexure model, we analyze the isostatically compensated gravity signature of these basins. Our approach is based on previously published basin formation models using the iSALE-2D shock physics code. Here we investigate how isostatic compensation processes alter the gravity signature using models of basin formation as initial conditions. We compare our results with the present day observed gravity data. We assume that isostatic compensation is the result of flexural deformation of the crust-mantle boundary with varying lithospheric elastic thicknesses. Our results indicate that the effect of isostatic compensation on the gravity signature varies depending on the thermal conditions at the time of impact. We find that despite this variability, the overall influence of isostatic compensation on the gravity signature is generally moderate to minor. Additionally, our analysis is consistent with previous studies that have shown that the elastic thickness varies across the Moon. Our findings contribute to our understanding of the relationship between basin formation and the thermal evolution of the Moon. The variations in elastic thickness found provide nuanced insights into lunar geological processes and improve our understanding of the early history of the Moon.
View lessThe study of environmental ancient DNA provides us with the unique opportunity to link environmental with ecosystem change over a millennial timescale. Paleorecords such as lake sediments contain genetic pools of past living organisms that are a valuable source of information to reconstruct how ecosystems were and how they changed in response to climate in the past. Here, we report on paleometagenomics of a sedimentary record in northern Siberia covering the past 6700 years. We integrated taxonomic with functional gene analysis, which enabled to shed light not only on community compositions but also on eco-physiological adaptations and ecosystem functioning. We reconstructed the presence of an open boreal forest 6700 years ago that over time was gradually replaced by tundra. This vegetation change had major consequences on the environmental microbiome, primarily enriching bacterial and archaeal ammonia oxidizers (e.g., Nitrospira, Nitrosopumilus, and Ca. Nitrosocosmicus) in the tundra ecosystem. We identified a core microbiome conserved through time and largely consisting of heterotrophic bacteria of the Bacteroidetes phylum (e.g., Mucilaginibacter) harboring numerous functional genes for degradation of plant-biomass and abiotic and biotic stress resistance. Archaea were also a key functional guild, involved in nitrogen and carbon cycling, not only methanogenesis but possibly also degradation of plant material via enzymes such as cellulases and amylases. Overall, the paleo-perspective offered by our study can have a profound impact on modern climate change biology, by helping to explain and predict the ecological interplay among multiple ecosystem levels based on past experiences.
View lessIn this work, we analyzed trifluoromethyl fluorosulfonate (CF3OSO2F) and trifluoromethoxy sulfur pentafluoride (CF3OSF5) regarding their potential use as dielectrics by investigating some of their intrinsic and extrinsic properties. Both compounds show a higher breakdown voltage than SF6 with averaged relative breakdown voltages of 1.3±0.2 for CF3OSO2F and 1.4±0.2 for CF3OSF5 compared to SF6 with 1.0. Like the dielectric (CF3)2CFCN, both compounds decompose during the breakdown process. The decomposition products were analyzed by IR spectroscopy and GCIR methods. Furthermore, the molecular structures of both gaseous compounds CF3OSO2F and CF3OSF5 have been determined by in situ crystallization, and their physical properties were determined as well.
View lessDecreased long-range temporal correlations (LRTC) in brain signals can be used to measure cognitive effort during task execution. Here, we examined how learning a motor sequence affects long-range temporal memory within resting-state functional magnetic resonance imaging signal. Using the Hurst exponent (HE), we estimated voxel-wise LRTC and assessed changes over 5 consecutive days of training, followed by a retention scan 12 days later. The experimental group learned a complex visuomotor sequence while a complementary control group performed tightly matched movements. An interaction analysis revealed that HE decreases were specific to the complex sequence and occurred in well-known motor sequence learning associated regions including left supplementary motor area, left premotor cortex, left M1, left pars opercularis, bilateral thalamus, and right striatum. Five regions exhibited moderate to strong negative correlations with overall behavioral performance improvements. Following learning, HE values returned to pretraining levels in some regions, whereas in others, they remained decreased even 2 weeks after training. Our study presents new evidence of HE's possible relevance for functional plasticity during the resting-state and suggests that a cortical subset of sequence-specific regions may continue to represent a functional signature of learning reflected in decreased long-range temporal dependence after a period of inactivity.
View lessWater tanks as traditional rainwater harvesting systems for agriculture are widely distributed in South India. They have a strong impact on hydrological processes, affecting streamflow in rivers as well as evapotranspiration. This study aims at an accurate representation of water harvesting systems in a hydrologic model to improve model performance and assessment of the catchment water balance. To this end, spatio-temporal variations of water bodies between the years 2016 and 2018 and the months of January and May 2017 were derived from Sentinel-2 satellite data to parameterize the water tanks (reservoir) parameters in the Soil and Water Assessment Tool (SWAT+) model of the Adyar basin, Chennai, India. Approximately 16% of the basin is covered by water tanks. The initial model performance was evaluated for two model setups, with and without water tanks. The best model run was selected with a multi-metric approach comparing observed and modelled monthly streamflow for 5000 model runs. The final model evaluation was carried out by comparing estimated water body areas by the model and remote sensing observations for January to May 2017. The results showed that representing water tanks in the hydrologic model led to an improvement in the representation of the seasonal variations of streamflow for the whole simulation period (2004–2018). The model performance was classified as good and very good for the calibration (2004–2011) and validation (2012–2018) periods as NSE varies between 0.67 and 0.85, KGE varies between 0.65 and 0.72, PBIAS varies between −24.1 and −23.6, and RSR varies between 0.57 and 0.39. The best fit was shown for the high and middle flow segments of the hydrograph where the coefficient of determination (R2) ranges from 0.81 to 0.97 and 0.75 to 0.81, respectively. The monthly variation of water body areas in 2017 estimated by the hydrologic model was consistent with changes observed in remote sensing surveys. In summary, the water tank parametrization using remote sensing techniques enhanced the hydrologic model's efficiency and applicability for future studies.
View lesshe adoption of COVID-19 contact tracing apps (CTAs) has been proposed as an important measure to contain the spread of COVID-19. Based on a cross-national dataset, this article analyzes public perceptions toward CTAs and the factors that drive CTA acceptance in China, Germany, and the United States. We find that public acceptance of CTAs is significantly higher in China as compared with Germany and the United States. Despite very different sociopolitical contexts, there are striking similarities in the factors that drive CTA acceptance in all three countries. Citizens are willing to accept digital contact tracing despite concerns about privacy infringement and government surveillance, as long as the apps are perceived as effective in lowering infection rates and providing health information. This creates a chicken-and-egg problem for CTAs in Germany and the United States where CTAs are voluntary: a high citizen adoption rate is necessary for CTAs to be effective, but CTAs are only effective if adoption rates are high.
View lessSituational judgment tests (SJTs) are popular instruments in selection and assessment. However, the application of SJTs to non-Western cultural contexts remains scarce. In this study, we investigated whether an SJT on personal initiative, developed in Germany and translated into Cuban Spanish, had similar psychometric properties in Cuba. Second, there is an ongoing debate about the extent to which the situation description plays an important role for SJTs. We supposed that the impact of situation descriptions might depend on test takers’ familiarity with the culture in which the SJT was developed. Hence, we tested whether the omission of situation descriptions had larger effects in a Cuban than in a German sample. We applied a 2 (with vs. without situation description in the item stem) × 2 (cultural background: Cuba vs. Germany) between-subjects design (NCuba = 192, NGermany = 213). The results revealed similar psychometric properties between Cuban and German test takers concerning measurement invariance, construct-related validity, and reliability. In addition, we examined whether samples differ regarding applicant perceptions: Notably, for four of six applicant perception scales, the Cuban sample reported a more positive view of the SJT. Furthermore, we found that the effect of situation availability on SJT performance did not substantially depend on the test takers’ cultural background. Implications for cross-cultural generalizability are discussed.
View lessCompanionship is related to better affect and relationship satisfaction, but few studies have examined both partners' perspectives over time and the link between companionship and health. In three intensive longitudinal studies (Study 1: 57 community couples; Study 2: 99 smoker–nonsmoker couples; Study 3: 83 dual-smoker couples), both partners reported daily companionship, affect, relationship satisfaction, and a health behavior (smoking in Studies 2 and 3). We proposed a dyadic score model that focuses on the couple level for companionship as a dyadic predictor with considerable shared variance. On days with higher companionship, couples reported better affect and relationship satisfaction. When partners differed in companionship, they also differed in affect and relationship satisfaction. For smoking, a different picture emerged: Whereas smokers with nonsmoking partners smoked less on average with higher companionship, smokers with smoking partners smoked more on days with higher companionship. Findings show companionship as a consequential relationship construct deserving further study. Using the dyadic score model acknowledged both partners' perspectives on companionship. It demonstrated higher precision for detecting effects of partner averages in a dyadic predictor compared with traditional approaches, tests for effects of partner differences in a dyadic predictor and in outcome while maintaining the focus on the dyad.
View lessOver the past 3 years, employees have constantly witnessed how their organizations have responded to the challenges posed by the COVID-19 pandemic. Here, we hypothesize that employees' perceptions of the COVID-19 safety climate of their organization positively affect their vaccine readiness. To examine the underlying mechanisms of this effect, we use a self-perception theory lens. Thus, we hypothesize that an organization's COVID-19 safety climate affects employees' COVID-19 vaccine readiness through employees' adherence to COVID-19 guidelines. We conducted a time-lagged study over the time span of 1 year (N = 351) to test our hypotheses. In general, results support our hypotheses. In particular, results showed that perceived COVID-19 safety climate assessed at an early stage of the pandemic (April 2020, when no vaccines were available) predicted employees' COVID-19 vaccine readiness more than a year later. In line with self-perception theory, this effect was mediated by employees' adherence to COVID-19 guidelines. The present study provides theoretical insight into the underlying mechanisms of organizational climate on employees' attitudes. From a practical perspective, our results suggest that organizations are a powerful lever for promoting vaccine readiness.
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