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The effect of antibiotic use on prevalence of nosocomial vancomycin-resistant enterococci
Remschmidt, Cornelius ;  Behnke, Michael ;  Kola, Axel ;  Diaz, Luis A. Pena ;  Rohde, Anna M. ;  Gastmeier, Petra ;  Schwab, Frank

HaupttitelThe effect of antibiotic use on prevalence of nosocomial vancomycin-resistant enterococci
TitelzusatzAn ecologic study
AutorRemschmidt, Cornelius
AutorBehnke, Michael
AutorKola, Axel
AutorDiaz, Luis A. Pena
AutorRohde, Anna M.
AutorGastmeier, Petra
AutorSchwab, Frank
Seitenzahl8 Seiten
Freie SchlagwörterVancomycin-resistant enterococcus; Transmission; Antibiotic use; Carbapenems; Glycopeptides
DDC610 Medizin und Gesundheit
615 Pharmakologie, Therapie
Auch erschienen inAntimicrobial Resistance & Infection Control. - 6 (2017), 95
ZusammenfassungBackground:
Vancomycin-resistant enterococci (VRE) are among the most common antimicrobial-resistant pathogens causing nosocomial infections. Although antibiotic use has been identified as a risk factor for VRE, it remains unclear which antimicrobial agents particularly facilitate VRE selection. Here, we assessed whether use of specific antimicrobial agents is independently associated with healthcare-associated (HA) VRE rates in a university hospital setting in Berlin, Germany
.
Methods:
We conducted the study between January 2014 and December 2015 at the Charité-university hospital of Berlin, Germany. From the hospital pharmacy, we extracted data for all antibacterials for systemic use (anatomical therapeutic chemical (ATC)-classification J01) and calculated ward specific antibiotic consumption in defined daily doses (DDDs) per 100 patient-days (PD). We used the microbiology laboratory database to identify all patients with isolation of invasive or non-invasive VRE and calculated HA-VRE incidence as nosocomial VRE-cases per 100 patients and HA-VRE incidence density as nosocomial VRE-cases per 1000 PD. We defined VRE isolates as hospital-acquired if they were identified three days or later after hospital admission and otherwise as community-acquired (CA-VRE). We performed univariable and multivariable regression analyses to estimate the association of the frequency of HA-VRE per month with antibiotic use and other parameters such as length of stay, type of ward or presence of at least one CA-VRE on ward. In a second analysis, we considered only patients with VRE infections.

Results:
We included data from 204,054 patients with 948,380 PD from 61 wards. Overall, 1430 VRE-cases were identified of which 409 (28.6%) were considered hospital-acquired (HA). We found that carbapenem use in the current month and prior-month use of glycopeptides increased the risk for HA-VRE by 1% per 1 DDD/100 PD and 3% per 1 DDD/100 PD, respectively. However, when only VRE from clinical samples were considered, only glycopeptide use showed a statistically significant association. In both models, detection of at least one patient with CA-VRE on a ward in the current month significantly increased the risk of HA-VRE, thereby indicating nosocomial spread of VRE.

Conclusions:
Our findings suggest that the risk of HA-VRE is associated with specific antimicrobial agents. Prudent use of these antimicrobial agents might reduce nosocomial VRE rates. That appearance of at least one CA-VRE case on the ward increased the risk of HA-VRE detection highlights the importance of strict hand hygiene practices to interrupt person-to-person transmission of VRE.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer Open-Access-Zeitschrift publiziert.
Erstellt am12.10.2017 - 13:59:40
Letzte Änderung12.10.2017 - 14:00:18
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000028299
DOI10.1186/s13756-017-0253-5
ISSN2047-2994
Zugriffsstatistik
 

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