Objekt-Metadaten
| The effect of antibiotic use on prevalence of nosocomial vancomycin-resistant enterococci Remschmidt, Cornelius ; Behnke, Michael ; Kola, Axel ; Diaz, Luis A. Pena ; Rohde, Anna M. ; Gastmeier, Petra ; Schwab, Frank |
| Haupttitel | The effect of antibiotic use on prevalence of nosocomial vancomycin-resistant enterococci |
| Titelzusatz | An ecologic study |
| Autor | Remschmidt, Cornelius |
| Autor | Behnke, Michael |
| Autor | Kola, Axel |
| Autor | Diaz, Luis A. Pena |
| Autor | Rohde, Anna M. |
| Autor | Gastmeier, Petra |
| Autor | Schwab, Frank |
| Seitenzahl | 8 Seiten |
| Freie Schlagwörter | Vancomycin-resistant enterococcus; Transmission; Antibiotic use; Carbapenems; Glycopeptides |
| DDC | 610 Medizin und Gesundheit 615 Pharmakologie, Therapie |
| Auch erschienen in | Antimicrobial Resistance & Infection Control. - 6 (2017), 95 |
| Zusammenfassung | Background: Vancomycin-resistant enterococci (VRE) are among the most common antimicrobial-resistant pathogens causing nosocomial infections. Although antibiotic use has been identified as a risk factor for VRE, it remains unclear which antimicrobial agents particularly facilitate VRE selection. Here, we assessed whether use of specific antimicrobial agents is independently associated with healthcare-associated (HA) VRE rates in a university hospital setting in Berlin, Germany . Methods: We conducted the study between January 2014 and December 2015 at the Charité-university hospital of Berlin, Germany. From the hospital pharmacy, we extracted data for all antibacterials for systemic use (anatomical therapeutic chemical (ATC)-classification J01) and calculated ward specific antibiotic consumption in defined daily doses (DDDs) per 100 patient-days (PD). We used the microbiology laboratory database to identify all patients with isolation of invasive or non-invasive VRE and calculated HA-VRE incidence as nosocomial VRE-cases per 100 patients and HA-VRE incidence density as nosocomial VRE-cases per 1000 PD. We defined VRE isolates as hospital-acquired if they were identified three days or later after hospital admission and otherwise as community-acquired (CA-VRE). We performed univariable and multivariable regression analyses to estimate the association of the frequency of HA-VRE per month with antibiotic use and other parameters such as length of stay, type of ward or presence of at least one CA-VRE on ward. In a second analysis, we considered only patients with VRE infections. Results: We included data from 204,054 patients with 948,380 PD from 61 wards. Overall, 1430 VRE-cases were identified of which 409 (28.6%) were considered hospital-acquired (HA). We found that carbapenem use in the current month and prior-month use of glycopeptides increased the risk for HA-VRE by 1% per 1 DDD/100 PD and 3% per 1 DDD/100 PD, respectively. However, when only VRE from clinical samples were considered, only glycopeptide use showed a statistically significant association. In both models, detection of at least one patient with CA-VRE on a ward in the current month significantly increased the risk of HA-VRE, thereby indicating nosocomial spread of VRE. Conclusions: Our findings suggest that the risk of HA-VRE is associated with specific antimicrobial agents. Prudent use of these antimicrobial agents might reduce nosocomial VRE rates. That appearance of at least one CA-VRE case on the ward increased the risk of HA-VRE detection highlights the importance of strict hand hygiene practices to interrupt person-to-person transmission of VRE. |
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| Fachbereich/Einrichtung | Medizinische Fakultät Charité - Universitätsmedizin Berlin |
| Erscheinungsjahr | 2017 |
| Dokumententyp/-Sammlungen | Wissenschaftlicher Artikel |
| Sprache | Englisch |
| Rechte |  This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Anmerkungen des Autors | Der Artikel wurde in einer Open-Access-Zeitschrift publiziert. |
| Erstellt am | 12.10.2017 - 13:59:40 |
| Letzte Änderung | 12.10.2017 - 14:00:18 |
| Statische URL | http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000028299 |
| DOI | 10.1186/s13756-017-0253-5 |
| ISSN | 2047-2994 |
| Zugriffsstatistik | |
