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Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
Schueler, Rita ;  Osterhoff, Martin A. ;  Frahnow, Turid ;  Moehlig, Matthias ;  Spranger, Joachim ;  Stefanovski, Darko ;  Bergman, Richard ;  Xu, Li ;  Seltmann, Anne-Cathrin ;  Kabisch, Stefan ;  Hornemann, Silke ;  Kruse, Michael ;  Pfeiffer, Andreas F. H.

HaupttitelDietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
AutorSchueler, Rita
AutorOsterhoff, Martin A.
AutorFrahnow, Turid
AutorMoehlig, Matthias
AutorSpranger, Joachim
AutorStefanovski, Darko
AutorBergman, Richard
AutorXu, Li
AutorSeltmann, Anne-Cathrin
AutorKabisch, Stefan
AutorHornemann, Silke
AutorKruse, Michael
AutorPfeiffer, Andreas F. H.
Seitenzahl7 S.
Freie SchlagwörterClinical trials; Genetic interaction
DDC610 Medizin und Gesundheit
Auch erschienen inScientific Reports. - 7 (2017), Artikel Nr. 9234
ZusammenfassungThe frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore investigated its potential nutrigenetic role in glucose metabolism. In this nutritional intervention study 46 healthy and non-obese twin pairs consumed recommended low fat diets for 6 weeks before they received a 6-week high fat (HF) diet under isocaloric conditions. Intravenous glucose tolerance tests were performed before and after 1 and 6 weeks of HF diet. While glucose tolerance did not differ between genotypes at baseline it significantly declined in GG-carriers after 6 weeks HF diet (p = 0.001) with higher 2 h glucose and insulin concentrations compared to AA/AG-carriers (p = 0.003 and p = 0.042). Furthermore, the gene-diet interaction was confirmed in the cross-sectional Metabolic Syndrome Berlin Potsdam study (p = 0.012), with the GG-genotypes being significantly associated with prevalent type 2 diabetes for participants with high dietary fat intake ≥37% (GG vs. AA/AG, OR 2.36 [1.02–5.49], p = 0.045). In conclusion, the association between the rs4343 variant and glucose tolerance is modulated by dietary fat intake. The ACE rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker potentially applicable for nutrigenetic dietary counseling.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am29.09.2017 - 10:26:34
Letzte Änderung29.09.2017 - 10:27:07
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000028059
DOI10.1038/s41598-017-08300-7
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