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Laser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function
Kubasch, Marie Luise ;  Kubasch, Anne Sophie ;  Pacheco, Juliana Torres ;  Buchmann, Sylvia J. ;  Illigens, Ben Min-Woo ;  Barlinn, Kristian ;  Siepmann, Timo

HaupttitelLaser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function
AutorKubasch, Marie Luise
AutorKubasch, Anne Sophie
AutorPacheco, Juliana Torres
AutorBuchmann, Sylvia J.
AutorIlligens, Ben Min-Woo
AutorBarlinn, Kristian
AutorSiepmann, Timo
Seitenzahl6 S.
Freie Schlagwörterlaser Doppler; imaging; flowmetry; skin; neuropathy; assessment; axon
DDC610 Medizin und Gesundheit
Auch erschienen inFront. Neurol. - 8 (2017), Artikel Nr. 370
ZusammenfassungThe vasomotor axon reflex can be evoked in peripheral epidermal nociceptive C-fibers to induce local vasodilation. This neurogenic flare response is a measure of C-fiber functional integrity and therefore shows impairment in patients with small fiber neuropathy. Laser Doppler flowmetry (LDF) and laser Doppler imaging (LDI) are both techniques to analyze vasomotor small fiber function by quantifying the integrity of the vasomotor-mediated axon reflex. While LDF assesses the flare response following acetylcholine iontophoresis with temporal resolution at a single defined skin point, LDI records flare responses with spatial and temporal resolution, generating a two-dimensional map of superficial blood flow. LDF is characterized by a high intra- and interindividual measurement variability, which is smaller in LDI due to its spatial resolution. Nevertheless, LDI still lacks standardized methods for image analysis. Consequently, use of the technique currently remains on an experimental level. Here, we sought to review the current literature on laser Doppler assessment of vasomotor function and discuss potential future applications of established techniques as well as those that are still experimental.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am25.09.2017 - 12:21:34
Letzte Änderung25.09.2017 - 12:22:07
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000028005
DOI10.3389/fneur.2017.00370
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