Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease
Merkl, Angela ;  Roeck, Eva ;  Schmitz-Huebsch, Tanja ;  Schneider, Gerd-Helge ;  Kuehn, Andrea A.

HaupttitelEffects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease
AutorMerkl, Angela
Autor Roeck, Eva
AutorSchmitz-Huebsch, Tanja
AutorSchneider, Gerd-Helge
AutorKuehn, Andrea A.
Seitenzahl9 S.
Freie Schlagwörterdeep brain stimulation; Parkinson’s disease; working memory; neuropsychiatric
DDC616 Krankheiten
Auch erschienen inNeuropsychiatric Disease and Treatment. - 13 (2017), S. 1603-1611
ZusammenfassungBackground: In Parkinson’s disease (PD), cognitive symptoms and mood changes may be even more distressing for the patient than motor symptoms.
Objective: Our aim was to determine the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on working memory (WM) and mood.
Methods: Sixteen patients with PD were assessed with STN-DBS switched on (DBS-ON) and with dopaminergic treatment (Med-ON) compared to switched off (DBS-OFF) and without dopaminergic treatment (Med-OFF). The primary outcome measures were a Visual Analog Mood Scale (VAMS) and an emotional 2-back WM task at 12 months after DBS in the optimal DBS-ON/Med-ON setting compared to DBS-OFF/Med-OFF.
Results: Comparison of DBS-OFF/Med-OFF to DBS-ON/Med-ON revealed a significant increase in alertness (meanoff/off =51.59±24.54; meanon/on =72.75; P=0.016) and contentedness (meanoff/off =38.73±24.41; meanon/on =79.01±17.66; P=0.001, n=16), and a trend for reduction in sedation (P=0.060), which was related to stimulation as shown in a subgroup of seven patients. The N-back task revealed a significant increase in accuracy with DBS-ON/Med-ON compared to DBS-OFF/Med-OFF (82.0% vs 76.0%, respectively) (P=0.044), regardless of stimulus valence.
Conclusion: In line with previous studies, we found that patients rated themselves subjectively as more alert, content, and less sedated during short-term DBS-ON. Accuracy in the WM task increased with the combination of DBS and medication, possibly related to higher alertness of the patients. Our results add to the currently mixed results described for DBS on WM and suggest that there are no deleterious DBS effects on this specific cognitive domain.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Dokumententyp/-SammlungenWissenschaftlicher Artikel
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am22.08.2017 - 09:42:01
Letzte Änderung22.08.2017 - 10:52:17
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000027594