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Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology
Dunst, Josefine ;  Azzouz, Nahid ;  Liu, Xinyu ;  Tsukita, Sachiko ;  Seeberger, Peter H. ;  Kamena, Faustin

HaupttitelInteraction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology
AutorDunst, Josefine
AutorAzzouz, Nahid
AutorLiu, Xinyu
AutorTsukita, Sachiko
AutorSeeberger, Peter H.
AutorKamena, Faustin
Seitenzahl160 Seiten
Freie SchlagwörterGPi; ERM; moesin; Plasmodium; cerebral malaria
DDC540 Chemie und zugeordnete Wissenschaften
572 Biochemie
Auch erschienen inFront. Cell. Infect. Microbiol. - 7 (2017), Artikel Nr. 183
ZusammenfassungGlycosylphosphatidylinositol (GPI) anchor of Plasmodium falciparum origin is considered an important toxin leading to severe malaria pathology through stimulation of pro-inflammatory responses from innate immune cells. Even though the GPI-induced immune response is widely described to be mediated by pattern recognition receptors such as TLR2 and TLR4, previous studies have revealed that these two receptors are dispensable for the development of severe malaria pathology. Therefore, this study aimed at the identification of potential alternative Plasmodium GPI receptors. Herein, we have identified the host protein moesin as an interaction partner of Plasmodium GPI in vitro. Given previous reports indicating the relevance of moesin especially in the LPS-mediated induction of pro-inflammatory responses, we have conducted a series of in vitro and in vivo experiments to address the physiological relevance of the moesin-Plasmodium GPI interaction in the context of malaria pathology. We report here that although moesin and Plasmodium GPI interact in vitro, moesin is not critically involved in processes leading to Plasmodium-induced pro-inflammatory immune responses or malaria-associated cerebral pathology.
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Fachbereich/EinrichtungFB Biologie, Chemie, Pharmazie
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Erstellt am24.05.2017 - 07:19:42
Letzte Änderung07.06.2017 - 08:23:38
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026995
DOI10.3389/fcimb.2017.00183
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