Objekt-Metadaten

NaviCom
Dorel, Mathurin ;  Viara, Eric ;  Barillot, Emmanuel ;  Zinovyev, Andrei ;  Kuperstein, Inna

HaupttitelNaviCom
Titelzusatza web application to create interactive molecular network portraits using multi-level omics data
AutorDorel, Mathurin
AutorViara, Eric
AutorBarillot, Emmanuel
AutorZinovyev, Andrei
AutorKuperstein, Inna
Seitenzahl11 S.
DDC610 Medizin und Gesundheit
Auch erschienen inDatabase (Oxford). - 2017 (2017), 1, Artikel Nr. bax026
ZusammenfassungHuman diseases such as cancer are routinely characterized by high-throughput molecular technologies, and multi-level omics data are accumulated in public databases at increasing rate. Retrieval and visualization of these data in the context of molecular network maps can provide insights into the pattern of regulation of molecular functions reflected by an omics profile. In order to make this task easy, we developed NaviCom, a Python package and web platform for visualization of multi-level omics data on top of biological network maps. NaviCom is bridging the gap between cBioPortal, the most used resource of large-scale cancer omics data and NaviCell, a data visualization web service that contains several molecular network map collections. NaviCom proposes several standardized modes of data display on top of molecular network maps, allowing addressing specific biological questions. We illustrate how users can easily create interactive network-based cancer molecular portraits via NaviCom web interface using the maps of Atlas of Cancer Signalling Network (ACSN) and other maps. Analysis of these molecular portraits can help in formulating a scientific hypothesis on the molecular mechanisms deregulated in the studied disease.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Erstellt am12.05.2017 - 10:52:42
Letzte Änderung12.05.2017 - 10:54:51
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026988
DOI10.1093/database/bax026
Zugriffsstatistik
 

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