Objekt-Metadaten

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans
Kessler, Katharina ;  Hornemann, Silke ;  Petzke, Klaus J. ;  Kemper, Margrit ;  Kramer, Achim ;  Pfeiffer, Andreas F. H. ;  Pivovarova, Olga ;  Rudovich, Natalia

HaupttitelThe effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans
Titelzusatza randomized controlled trial
AutorKessler, Katharina
AutorHornemann, Silke
AutorPetzke, Klaus J.
AutorKemper, Margrit
AutorKramer, Achim
AutorPfeiffer, Andreas F. H.
AutorPivovarova, Olga
AutorRudovich, Natalia
Seitenzahl14 S.
Freie SchlagwörterNutrition; Randomized controlled trials; Type 2 diabetes
DDC610 Medizin und Gesundheit
Auch erschienen inScientific Reports. - 7 (2017), Artikel Nr. 44170
ZusammenfassungDiurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients and its effects on glycaemic control after prolonged consumption are not studied in detail. In this cross-over trial, 29 non-obese men were randomized to two four-week diets: (1) carbohydrate-rich meals until 13.30 and fat-rich meals between 16.30 and 22.00 (HC/HF) versus (2) inverse sequence of meals (HF/HC). After each trial period two meal tolerance tests were performed, at 09.00 and 15.40, respectively, according to the previous intervention. On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026) in subjects with impaired fasting glucose and/or impaired glucose tolerance (IFG/IGT, n = 11), and GLP-1 by 10.2% (p = 0.041) in normal glucose-tolerant subjects (NGT, n = 18). Diet effects on fasting GLP-1 (p = 0.009) and PYY (p = 0.034) levels were observed in IFG/IGT, but not in NGT. Afternoon decline of glucose tolerance was more pronounced in IFG/IGT and associated with a stronger decrease of postprandial GLP-1 and PYY levels, but not with changes of cortisol rhythm. In conclusion, the HF/HC diet shows an unfavourable effect on glycaemic control in IFG/IGT, but not in NGT subjects. Consequently, large, carbohydrate-rich dinners should be avoided, primarily by subjects with impaired glucose metabolism.
Dokumente
PDF-Datei von FUDOCS_document_000000026951
Falls Ihr Browser eine Datei nicht öffnen kann, die Datei zuerst herunterladen und dann öffnen.
 
Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am05.05.2017 - 08:47:21
Letzte Änderung05.05.2017 - 08:52:16
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026951
DOI10.1038/srep44170
Zugriffsstatistik
 

LOADING...