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Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS
Stellmann, Jan-Patrick ;  Cetin, Hanife ;  Young, Kim Lea ;  Hodecker, Sibylle ;  Poettgen, Jana ;  Bittersohl, Diana ;  Hassenstein, Andrea ;  Oberwahrenbrock, Timm ;  Heesen, Christoph ;  Siemonsen, Susanne

HaupttitelPattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS
AutorStellmann, Jan-Patrick
AutorCetin, Hanife
AutorYoung, Kim Lea
Autor Hodecker, Sibylle
AutorPoettgen, Jana
AutorBittersohl, Diana
AutorHassenstein, Andrea
AutorOberwahrenbrock, Timm
AutorHeesen, Christoph
AutorSiemonsen, Susanne
Seitenzahl14 S.
DDC610 Medizin und Gesundheit
Auch erschienen inBrain and Behavior. - 7 (2017), 2, Artikel Nr. e00614
ZusammenfassungBackground

Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated.

Objective

To investigate the association between focal cortical volume and thickness of retinal layers.

Methods

Fifty-four patients (relapsing–remitting MS, mean age 40.5 years, mean disease duration 7.6 years, median EDSS 2) underwent OCT and MRI. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Patterns of association were determined with Yeo's functional network atlas and the Harvard-Oxford cortical atlas. We used GEE models with cortical volumes from the FreeSurfer parcellation to confirm VBM results. Post hoc, we analyzed the association between OCT, focal cortical volumes, and an extended neuropsychological assessment in a subgroup of 14 patients.

Results

Macular retinal nerve fiber layer (mRNFL) and ganglion cell /inner plexiform layer (GCIPL) showed a robust association with mainly the insular cortex and the cingulate cortex. VBM findings were confirmed with FreeSurfer volumes. The post hoc analysis detected significant correlations between both OCT outcomes and cognition.

Conclusion

Besides the primary visual system, OCT outcomes show a correlation pattern with cortical regions that are known to be important for cognitive performance, predominantly the insula in both hemispheres. Thus, OCT should be further investigated as a marker for neurodegeneration in MS.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am28.04.2017 - 09:25:59
Letzte Änderung28.04.2017 - 09:27:33
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026924
DOI10.1002/brb3.614
Zugriffsstatistik
 

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