Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment
Koebe, Theresa ;  Witte, A. Veronica ;  Schnelle, Ariane ;  Tesky, Valentina A. ;  Pantel, Johannes ;  Schuchardt, Jan-Philipp ;  Hahn, Andreas ;  Bohlken, Jens ;  Grittner, Ulrike ;  Floeel, Agnes

HaupttitelImpact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment
AutorKoebe, Theresa
AutorWitte, A. Veronica
AutorSchnelle, Ariane
AutorTesky, Valentina A.
AutorPantel, Johannes
AutorSchuchardt, Jan-Philipp
AutorHahn, Andreas
AutorBohlken, Jens
AutorGrittner, Ulrike
AutorFloeel, Agnes
Seitenzahl11 S.
Freie Schlagwörterhippocampus; memory performance; MCI; resting-state functional connectivity; resveratrol
DDC610 Medizin und Gesundheit
Auch erschienen inFront. Neurosci. - 11 (2017), Artikel Nr. 105
ZusammenfassungIn healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50–80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) (n = 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVARM p = 0.059, Cohen's d = 0.66), higher RSFC between right anterior hippocampus and right angular cortex (p < 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVARM p = 0.061, Cohen's d = 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Dokumententyp/-SammlungenWissenschaftlicher Artikel
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am19.04.2017 - 08:31:04
Letzte Änderung19.04.2017 - 08:33:07
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026827