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National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
Hauser, A. ;  Hofmann, A. ;  Hanke, K. ;  Bremer, V. ;  Bartmeyer, B. ;  Kuecherer, C. ;  Bannert, N.

HaupttitelNational molecular surveillance of recently acquired HIV infections in
Germany, 2013 to 2014
AutorHauser, A.
AutorHofmann, A.
AutorHanke, K.
AutorBremer, V.
AutorBartmeyer, B.
AutorKuecherer, C.
AutorBannert, N.
Seitenzahl8 S.
DDC610 Medizin und Gesundheit
Auch erschienen inEurosurveillance. - 22 (2017), 2, Artikel Nr. 3
ZusammenfassungTo enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p < 0.05). Non-B subtypes were also more frequently found in patients originating from countries other than Germany (46% vs 14%; p < 0.05) and in patients infected outside of Germany (63% vs 14%; p < 0.05).
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2017
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Erstellt am07.04.2017 - 08:38:35
Letzte Änderung07.04.2017 - 08:45:01
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026799
DOI10.2807/1560-7917.ES.2017.22.2.30436
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