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Poorly Differentiated Medullary Phenotype Predicts Poor Survival in Early Lymph Node-Negative Gastro-Esophageal Adenocarcinomas
Treese, Christoph ;  Sanchez, Pedro ;  Grabowski, Patricia ;  Berg, Erika ;  Blaeker, Hendrik ;  Kruschewski, Martin ;  Haase, Oliver ;  Hummel, Michael ;  Daum, Severin

HaupttitelPoorly Differentiated Medullary Phenotype Predicts Poor Survival in Early Lymph Node-Negative Gastro-Esophageal Adenocarcinomas
AutorTreese, Christoph
AutorSanchez, Pedro
AutorGrabowski, Patricia
AutorBerg, Erika
AutorBlaeker, Hendrik
AutorKruschewski, Martin
AutorHaase, Oliver
AutorHummel, Michael
AutorDaum, Severin
Seitenzahl15 S.
DDC610 Medizin und Gesundheit
Auch erschienen inPLoS ONE. - 11 (2016), 12, Artikel Nr. e0168237
ZusammenfassungBackground

5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or stomach (AGE/S) in Caucasian patients is reported to be 60–80%. We aimed to identify prognostic markers for patients with UICC-I without lymph-node involvement (N0).

Methods

Clinical data and tissue specimen from patients with AGE/S stage UICC-I-N0, treated by surgery only, were collected retrospectively. Tumor size, lymphatic vessel or vein invasion, grading, classification systems (WHO, Lauren, Ming), expression of BAX, BCL-2, CDX2, Cyclin E, E-cadherin, Ki-67, TP53, TP21, SHH, Survivin, HIF1A, TROP2 and mismatch repair deficiency were analyzed using tissue microarrays and correlated with overall and tumor related survival.

Results

129 patients (48 female) with a mean follow-up of 129.1 months were identified. 5-year overall survival was 83.9%, 5-year tumor related survival was 95.1%.

Poorly differentiated medullary cancer subtypes (p<0.001) and positive vein invasion (p<0.001) were identified as risk factors for decreased overall—and tumor related survival. Ki-67 (p = 0.012) and TP53 mutation (p = 0.044) were the only immunohistochemical markers associated with worse overall survival but did not reach significance for decreased tumor related survival.

Conclusion

In the presented study patients with AGE/S in stage UICC-I-N0 had a better prognosis as previously reported for Caucasian patients. Poorly differentiated medullary subtype was associated with reduced survival and should be considered when studying prognosis in these patients.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2016
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Erstellt am17.02.2017 - 12:31:11
Letzte Änderung17.02.2017 - 12:45:07
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026366
DOI10.1371/journal.pone.0168237
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