Objekt-Metadaten

Ventricular‐Vascular Coupling in Marfan and Non‐Marfan Aortopathies
Loeper, Farina ;  Oosterhof, Jantine ;  van den Dorpel, Mark ;  van der Linde, Denise ;  Lu, Yaxin ;  Robertson, Elizabeth ;  Hambly, Brett ;  Jeremy, Richmond

HaupttitelVentricular‐Vascular Coupling in Marfan and Non‐Marfan Aortopathies
AutorLoeper, Farina
AutorOosterhof, Jantine
Autorvan den Dorpel, Mark
Autorvan der Linde, Denise
AutorLu, Yaxin
AutorRobertson, Elizabeth
AutorHambly, Brett
AutorJeremy, Richmond
Seitenzahl18 S.
Freie Schlagwörteraneurysm; β‐blocker; matrix metalloproteinases; mechanics; myocardium
DDC610 Medizin und Gesundheit
Auch erschienen inJournal of the American Heart Association. - 5 (2016), 11, Artikel Nr. e003705
ZusammenfassungBackground: Marfan syndrome (MFS) and familial non–syndromal thoracic aortic aneurysm and dissection (ns‐TAAD) are genetic aortopathies causing aortic dilatation with increased aortic stiffness. Left ventricular (LV) contractility and ventricular‐vascular coupling index (VVI) were compared between MFS and ns‐TAAD and determinants of VVI were investigated.

Methods and Results: Patients with MFS (M 57, F 47) and ns‐TAAD (M 72, F 39) were studied by echocardiography and compared with controls (M 77, F 71). Aortic geometry, hemodynamics, LV work, LV contractility (end‐systolic elastance [Ees]), and VVI were documented. Aortic sinuses were equally dilated in MFS (19.7±2.4) and ns‐TAAD (19.8±1.8) compared to controls (16.2±1.4 mm·m−2, P<0.001). Aortic stiffness index was increased in MFS (9.7±5.1) and ns‐TAAD (10.8±4.7) versus controls (5.4±2.0, P<0.01); LV stroke work was unchanged in MFS (436±74) compared to controls (435±60) but increased in ns‐TAAD (492±109 mJ·m−2 P<0.01). The LV Ees was reduced in MFS (1.32±0.19) compared to controls (1.65±0.29 mm Hg·mL−1, P<0.01) but increased in ns‐TAAD (1.83±0.30, P<0.01) and VVI was abnormal in MFS (0.71±0.11) compared to controls (0.62±0.07, P<0.01) and ns‐TAAD (0.62±0.09). Treatment with β‐blockers was associated with partial normalization of VVI in MFS. A VVI ≥0.8 was associated with increased risk of death and heart failure in MFS.

Conclusions: Left ventricular contractility and ventricular‐vascular coupling are abnormal in MFS but preserved in ns‐TAAD, and are independent of aortic stiffness, consistent with intrinsic impairment of myocardial contractility in MFS.
Dokumente
PDF-Datei von FUDOCS_document_000000026332
Falls Ihr Browser eine Datei nicht öffnen kann, die Datei zuerst herunterladen und dann öffnen.
 
Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2016
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
Erstellt am14.02.2017 - 08:47:59
Letzte Änderung14.02.2017 - 08:48:56
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026332
DOI10.1161/JAHA.116.003705
Zugriffsstatistik
 

LOADING...