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A negative relationship between ventral striatal loss anticipation response and impulsivity in borderline personality disorder
Herbort, Maike C. ;  Soch, Joram ;  Wuestenberg, Torsten ;  Krauel, Kerstin ;  Pujara, Maia ;  Koenigs, Michael ;  Gallinat, Juergen ;  Walter, Henrik ;  Roepke, Stefan ;  Schott, Bjoern H.

HaupttitelA negative relationship between ventral striatal loss anticipation response and impulsivity in borderline personality disorder
AutorHerbort, Maike C.
AutorSoch, Joram
AutorWuestenberg, Torsten
AutorKrauel, Kerstin
AutorPujara, Maia
AutorKoenigs, Michael
AutorGallinat, Juergen
AutorWalter, Henrik
AutorRoepke, Stefan
AutorSchott, Bjoern H.
Seitenzahl13 S.
Freie SchlagwörterBorderline personality disorder; Reward; Loss; Monetary incentive delay; Impulsivity; Functional magnetic resonance imaging; Brain-behavior correlations
DDC610 Medizin und Gesundheit
Auch erschienen inNeuroImage: Clinical. - 12 (2016), S. 724-736
ZusammenfassungPatients with borderline personality disorder (BPD) frequently exhibit impulsive behavior, and self-reported impulsivity is typically higher in BPD patients when compared to healthy controls. Previous functional neuroimaging studies have suggested a link between impulsivity, the ventral striatal response to reward anticipation, and prediction errors. Here we investigated the striatal neural response to monetary gain and loss anticipation and their relationship with impulsivity in 21 female BPD patients and 23 age-matched female healthy controls using functional magnetic resonance imaging (fMRI). Participants performed a delayed monetary incentive task in which three categories of objects predicted a potential gain, loss, or neutral outcome. Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11). Compared to healthy controls, BPD patients exhibited significantly reduced fMRI responses of the ventral striatum/nucleus accumbens (VS/NAcc) to both reward-predicting and loss-predicting cues. BIS-11 scores showed a significant positive correlation with the VS/NAcc reward anticipation responses in healthy controls, and this correlation, while also nominally positive, failed to reach significance in BPD patients. BPD patients, on the other hand, exhibited a significantly negative correlation between ventral striatal loss anticipation responses and BIS-11 scores, whereas this correlation was significantly positive in healthy controls. Our results suggest that patients with BPD show attenuated anticipation responses in the VS/NAcc and, furthermore, that higher impulsivity in BPD patients might be related to impaired prediction of aversive outcomes.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2016
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Erstellt am03.02.2017 - 10:49:05
Letzte Änderung03.02.2017 - 10:52:30
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000026259
DOI10.1016/j.nicl.2016.08.011
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