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Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis
Moehle, Luisa ;  Mattei, Daniele ;  Heimesaat, Markus M. ;  Bereswill, Stefan ;  Fischer, Andre ;  Alutis, Marie ;  French, Timothy ;  Hambardzumyan, Dolores ;  Matzinger, Polly ;  Dunay, Ildiko R. ;  Wolf, Susanne A.

HaupttitelLy6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis
AutorMoehle, Luisa
AutorMattei, Daniele
AutorHeimesaat, Markus M.
AutorBereswill, Stefan
AutorFischer, Andre
AutorAlutis, Marie
AutorFrench, Timothy
AutorHambardzumyan, Dolores
AutorMatzinger, Polly
AutorDunay, Ildiko R.
AutorWolf, Susanne A.
Seitenzahl13 S.
DDC610 Medizin und Gesundheit
Auch erschienen inCell Reports. - 15 (2016), 9, S. 1945-1956
ZusammenfassungAntibiotics, though remarkably useful, can also cause certain adverse effects. We detected that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention. Reconstitution with normal gut flora (SPF) did not completely reverse the deficits in neurogenesis unless the mice also had access to a running wheel or received probiotics. In parallel to an increase in neurogenesis and memory retention, both SPF-reconstituted mice that ran and mice supplemented with probiotics exhibited higher numbers of Ly6Chi monocytes in the brain than antibiotic-treated mice. Elimination of Ly6Chi monocytes by antibody depletion or the use of knockout mice resulted in decreased neurogenesis, whereas adoptive transfer of Ly6Chi monocytes rescued neurogenesis after antibiotic treatment. We propose that the rescue of neurogenesis and behavior deficits in antibiotic-treated mice by exercise and probiotics is partially mediated by Ly6Chi monocytes.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2016
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer Open-Access-Zeitschrift publiziert.
Erstellt am08.07.2016 - 11:07:20
Letzte Änderung08.07.2016 - 11:10:54
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000024964
DOI10.1016/j.celrep.2016.04.074
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