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Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Douros, Antonios ;  Bronder, Elisabeth ;  Andersohn, Frank ;  Klimpel, Andreas ;  Kreutz, Reinhold ;  Garbe, Edeltraut ;  Bolbrinker, Juliane

HaupttitelHerb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
AutorDouros, Antonios
AutorBronder, Elisabeth
AutorAndersohn, Frank
AutorKlimpel, Andreas
AutorKreutz, Reinhold
AutorGarbe, Edeltraut
AutorBolbrinker, Juliane
Seitenzahl11 S.
Freie Schlagwörterhepatotoxicity; phytotherapeutics; pharmacovigilance
DDC615 Pharmakologie, Therapie
Auch erschienen inInt. J. Mol. Sci. - 17 (2016), 1, Artikel Nr. 114
ZusammenfassungHerb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than 180 Departments of all 51 Berlin hospitals from October 2002 to December 2011. Drug or herb intake was assessed through a standardized face-to-face interview. Drug or herbal aetiology was assessed based on the updated Council for International Organizations of Medical Sciences scale. In ten of all 198 cases of hepatotoxicity included in the study, herbal aetiology was assessed as probable (once ayurvedic herb) or possible (Valeriana five times, Mentha piperita once, Pelargonium sidoides once, Hypericum perforatum once, Eucalyptus globulus once). Mean age was 56.4 ± 9.7 years, and the predominant pattern of liver injury was hepatocellular. No cases of acute liver failure or death were observed. This case series corroborates known risks for ayurvedic herbs, supports the suspected association between Valeriana use and liver injury, and indicates a hepatotoxic potential for herbs such as Pelargonium sidoides, Hypericum perforatum or Mentha piperita that were rarely associated with liver injury before. However, given that possible causality does not prove clinical significance, further studies in this field are needed.
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Fachbereich/EinrichtungMedizinische Fakultät Charité - Universitätsmedizin Berlin
Erscheinungsjahr2016
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
RechteCreative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anmerkungen des AutorsDer Artikel wurde in einer Open-Access-Zeitschrift publiziert.
Erstellt am07.07.2016 - 09:07:42
Letzte Änderung07.07.2016 - 09:08:27
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000024956
DOI10.3390/ijms17010114
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