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Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali
Mungube, Erick O ;  Vitouley, Hervé S ;  Allegye-Cudjoe, Emmanuel ;  Diall, Oumar ;  Boucoum, Zakaria ;  Diarra, Boucader ;  Sanogo, Yousouf ;  Randolph, Thomas ;  Bauer, Burkhard ;  Zessin, Karl-Hans ;  Clausen, Peter Henning

HaupttitelDetection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali
AutorMungube, Erick O
AutorVitouley, Hervé S
AutorAllegye-Cudjoe, Emmanuel
AutorDiall, Oumar
AutorBoucoum, Zakaria
AutorDiarra, Boucader
AutorSanogo, Yousouf
AutorRandolph, Thomas
AutorBauer, Burkhard
AutorZessin, Karl-Hans
AutorClausen, Peter Henning
Seitenzahl9 S.
Freie SchlagwörterCattle; Trypanosomosis risk; Trypanocide resistance; Mali
DDC570 Biowissenschaften; Biologie
Auch erschienen inParasites and Vectors. 2012 Aug 1;5:155.
ZusammenfassungBackground
Tsetse fly-transmitted African animal trypanosomosis causes annual losses that run into billions of dollars. The disease is assumed to cause hunger and poverty in most sub-Saharan countries since it represents a serious impediment to sustainable livestock production. Both a cross-sectional and a longitudinal study were carried out from November to December 2007 to evaluate trypanosomosis risk and susceptibility of trypanosomes to trypanocidal drug treatment in village cattle populations in south-east Mali.

Methods
Eight purposively selected villages participated in the study. In each village, eight traps deployed along drainage lines over 24hour duration were used to catch tsetse. One hundred systematically selected cattle in the study villages were examined for trypanosomes. All trypanosome-positive cattle were randomly allocated into two treatment groups: a group treated with 0.5 mg/kg bw. isometamidium chloride (ISMM) and a group treated with 3.5 mg/kg bw. diminazene aceturate (DIM). The cattle were monitored for trypanosomes at day 14 and 28 post-treatment.

Results
Of the 796 cattle examined, 125 (15.7%) were trypanosome-positive. Village trypanosome prevalences ranged between 11% and 19%. There were no significant (p > 0.05) differences in the village trypanosome prevalences. Trypanosoma congolense was the dominant trypanosome species accounting for 73% (91/125) of the infections and T. vivax the remainder. Twenty (31.7%) of the 63 cattle on 0.5 mg/kg bw. ISMM treatment were still positive14 days post-treatment. Of the 43 aparasitaemic cattle monitored to day 28, 25.6% (11) became parasitaemic, resulting in a cumulative failure rate of 49.2% (31/63). Trypanosoma congolense accounted for 77.4% (24/31) of failed ISMM treatments. The 62 cattle treated with 3.5 mg/kg bw. DIM resulted in 30.6% (19/62) failed treatments. Although 42.2% (19/45) of T. congolense positive cattle did not respond to DIM treatment, all T. vivax positive cattle responded positively to DIM treatment.

Conclusions
The overreliance on trypanocides in the control of trypanosomosis will ultimately lead to multiple drug-resistant trypanosome populations as detected in villages in south-east Mali rendering the use of drugs doubtful. Effective alternative methods for trypanosomosis control ought to substitute chemotherapy to ensure sustainable cattle production in these villages. Since there is no single strategy for containing trypanocidal drug resistance, promotion of an integrated approach combining proven trypanosomosis control approaches in high trypanosomosis risk areas is most desirous. The best-bet strategy this study recommended for areas with multiple drug resistance included area-wide community tsetse control, control of co-infections to exploit self-cure against resistant trypanosome populations and the rational use of trypanocidal drugs which should be urgently promoted at all levels as a way of containing or reversing resistance.
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Fachbereich/EinrichtungFB Veterinärmedizin
Arbeitsbereich/InstitutInstitute for Parasitology and Tropical Veterinary Medicine
Erscheinungsjahr2012
Dokumententyp/-SammlungenWissenschaftlicher Artikel
SpracheEnglisch
Rechte Creative Commons License
Dieses Werk ist unter einer Creative Commons-Lizenz lizenziert.
Anmerkungen des AutorsGefördert durch die Deutsche Forschungsgemeinschaft und den Open-Access-Publikationsfonds der Freien Universität Berlin
Erstellt am30.10.2012 - 09:05:54
Letzte Änderung10.01.2014 - 10:29:01
 
Statische URLhttp://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000014797
DOI10.1186/1756-3305-5-155
Zugriffsstatistik