We found the gene SARS to be exclusively downregulated in our validation experiments in 50 paired prostate cancer specimens. This gene has not been described so far for its diminished expression in prostate cancer. This specific downregulation of SARS is most probably due to epigenetic downregulation by promoter hypermethylation. GADD45A, GSTP1 and SPRY4, reported to be hypermethylated in prostate cancer by others, were downregulated in our sample set, too.
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